Welcome to the the European Carotid Surgery Trial 2 (ECST-2) website.

ECST-2 (ISRCTN 97744893) is an international randomised trial investigating the optimal treatment of patients with symptomatic or asymptomatic moderate or severe carotid stenosis at low or intermediate risk of future stroke. The trial compares the risks and benefits of treatment by modern optimized medical management alone versus the addition of immediate carotid surgery (or stenting) to optimised medical management. The trial is currently recruiting new centres and participants

The initial phase of The European Carotid Surgery Trial 2 was funded by the National Institute for Health Research (NIHR) under its Research for Patient Benefit Programme. The trial is currently funded by the Stroke Association, UK.

This website provides information about the trial for participants in the trial, and for collaborators. If you have any questions about the trial, please feel free to contact us. Please use the navigation bar on the left to navigate around the site.

ECST-2 and ACST-2 -Complementary trials

ECST-2 and ACST-2 both seek to recruit patients with asymptomatic carotid artery stenosis, but the trials are not competing for patients because the questions they ask are different and complementary. ACST-2 is recruiting patients in whom it has been decided that revascularisation of asymptomatic stenosis is definitely required, but the clinicians are uncertain whether stenting or endarterectomy should be used. Patients in ACST-2 are therefore randomised between carotid endarterectomy and stenting. ECST-2 is recruiting patients with asymptomatic or symptomatic carotid stenosis in whom the clinicians are uncertain whether revascularisation is required. Patients in ECST-2 are randomised to immediate revascularisation or initial optimised medical management alone. All the patients in both trials will have appropriate medical management.

For Investigators

- download the CAR score app to perform rapid screening of symptomatic patients on your iPhone or Android tablet

- Click HERE to download the iOS version

- Click HERE to download the Android version

- Alternatively you can click HERE to use the online version

- go to the patient management site (you will need your username and password)

Screen a Patient Randomise a previously screened patient Enter data for an enrolled patient



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